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01 April 2016

Nature Reviews Drug Discovery: ‘European Lead Factory hits its stride’

Today, Nature Reviews Drug Discovery published a News & Analysis article: ‘European Lead Factory hits its stride.’

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23 March 2016

IHL phase passes the thousand compounds mark for public programmes

Public target programmes that have received a promising Qualified Hit List (QHL) have the possibility to continue their collaboration with the European Lead Factory with the aim of producing an Improved Hit List (IHL). 

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27 January 2016

European Lead Factory has commenced a drug screening campaign for one of Effecta Pharma’s Dengue viral targets

"We are excited we can continue our initial collaboration with the EU Lead Factory and its European Screening Centre researchers in Oss, Oxford and  Newhouse, which has yielded a screenable assay for one of the critical Dengue virus proteins. Having the EU Lead Factory as part of our concerted effort to generate preclinical candidates for Dengue  is welcome support for Effecta and the patients suffering from this disease”, Effecta’s Directors Helmuth van Es and Paul Edwards said.

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22 January 2016

EU Lead Factory Early Career Researcher Event showcases novel ideas in Medicinal and Synthetic Chemistry in Barcelona, Spain

The European Lead Factory acknowledges the need for open exchange between researchers with different professional background and puts a focus on the career development of young scientists.

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21 December 2015

JECL sparks Drug Discovery community interest

Just one month after publication, the Drug Discovery Today article by Karawajczyk et al describing the quality of the JECL public compounds has reached Top 5 of the most downloaded articles of this prestigious journal.

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16 December 2015

The European Lead Factory has achieved significant milestones for 2015

400,000 novel drug-like compounds are now compiled in the Joint European Compound Library (JECL); and 60 drug targets have been selected for screening.

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16 December 2015

TI Pharma is now Lygature

Top Institute Pharma (TI Pharma), one of the partners in the EU Lead Factory, will be named Lygature as from January 1st 2016.

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14 December 2015

Award-winning HDB software published in Drug Discovery Today

The Honest Data Broker (HDB), a cloud-based informatics system, has been developed specifically to balance the intellectual property and scientific requirements of the consortium partners regarding the unique HTS screening and triage workflow within the EU Lead Factory.

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10 December 2015

The Netherlands Translational Research Center (NTRC) has identified IDO1 inhibitors with best-in-class properties

They have been developed from a series of inhibitor compounds first identified by screening the JECL of the European Lead Factory against IOD1 and TDO, important targets in cancer immunotherapy.

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09 December 2015

Patent filed for European Lead Factory compounds

Within 3 years after the launch of the European Lead Factory, the first patent protecting the outcomes of a drug target programme has been filed. The patent addresses multidrug resistance in bacterial infections. This important milestone reflects the EU Lead Factory’s ability to deliver on its promise, and highlights the potential of this shared-innovation approach to drug discovery.

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