ELF: the talk of the international Medicinal Chemistry community at EFMC

12 September 2016

European Lead Factory noticeably stated its presence during the XXIV EFMC International Symposium on Medicinal Chemistry (EFMC-ISMC 2016) that took place last week in Manchester, European City of Science 2016.

EU Lead Factory was represented by 9 partners presenting their work in several posters (5 from academia and 7 from industry). The focus of the presented EU Lead Factory work was on the diversity and optimal physicochemical characteristics of the libraries produced for Public Compound Collection (PCC). Four poster presentations were sponsored by the EU Lead Factory industry partners: Dr Jurgen Brem, University of Oxford, related to the screening of antibacterial agents and Dr Ritika Sethi, Universtiy of Oxford, showing the crystal exploration in EU Lead Factory drug discovery; Dr Carlos Azevedo, Denmark Technical University, presenting natural-like small molecules libraries; and Dr Jalindar Padwal, Leiden University, highlighting sugar chemistry libraries.

The wide public of experts in the medicinal chemistry field created a perfect audience for Dr Mario van der Stelt from Leiden University to for the first time disclose bioactive ELF compounds structures EU Lead Factory results in the form of an oral communication on selective diacylglycerol lipase alpha inhibitors for the treatment of neurodegenerative diseases.

A substantial interest in the community for the attractive chemical structures of the PCC was recorded not only during the poster sessions but also during the whole conference in the Exhibitors booths, where EU Lead Factory was represented by the five chemistry SMEs partners. The asset of the consortium was widely recognized as novel, full of potential set of starting points for early drug discovery projects. 

This biennial key medicinal chemistry symposium attracted this year 975 participants from industry and academia. Continuing the tradition of covering recent progress in drug research in major therapeutic areas, treatment of pain, CNS disorders, infections, cardiovascular diseases and cancer were the main topics.