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European Lead Factory successfully creates ‘drug-like’ hit compounds

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Just a few months after its inclusion for drug target screening, one of the first compounds synthesised within the European Lead Factory was identified as a ‘drug-like’ hit. The compounds were synthesised by the Public Chemistry Consortium, based on library proposals from academic groups and small- and medium-sized enterprises (SMEs) in Europe.

The EU Lead Factory carefully selects library proposals for novelty, drug-like properties, diversity and synthetic tractability. The hit compound was among the first compounds to be synthesised for the EU Lead Factory, and was added to the Joint European Compound Library (JECL) along with 28,000 other compounds in January 2015. In addition to the hit compound, another 130 compounds have already been identified as ‘preliminary hits’ over multiple drug-target screening programmes in only five months, highlighting the potential of compounds synthesised from library proposals.

Together with over 300,000 high-quality compounds contributed by the seven pharmaceutical companies within the European Lead Factory, the JECL currently holds around 350,000 compounds. The collection is available for screening against novel drug targets and will continue to grow.

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