Janssen Campus Beerse, Belgium – 6 - 7 November 2017

Agenda 6 November 2017
 

08:30Arrival at Janssen Campus (Bus transfer: 07:35 from Hotel Priorij Corsedonk, 07:55 from Corsedonk Viane)09:00 - 10:00Introduction by Dimitrios Tzalis (Taros Chemicals) and Ton Rijnders (Lygature) (Auditorium - B150)Oral Presentation Session I (auditorium - B150)10:00 - 10:30 "Chemical Proteomics in Drug Discovery" by M. Van der Stelt (Leiden Univ.)10:30 - 10:45O02: "Key Reactions in Scaffold Design" by Y. Macé (Edelris)10:45 - 11:15Coffee break (Auditorium - B150)11:15 - 11:30O03: "Towards Libraries of Artificial Macrocycles using MCR" by E. MM Abdelraheem (Groningen Univ.)11:30 - 11:45O04: "Novel Azole-based Scaffolds for Drug Discovery" by M. Corpet (Taros Chemicals)11:45 - 12:00O05: "Efficient Access to b-lactam Containing Scaffolds" by G. Janssen (LUMC)12:00 - 12:15O06: "Learnings and Achievements from the European Lead Factory" by D. Hamza (Sygnature Discovery)12:15 - 12:30O07: "Macrocycle: A Validation Story" by R. Morgentin (Edelris)12:30 - 14:00Lunch including Poster Session of ELF Partners (P01-P13; Atrium - B020)OralPresentation Session II (Auditorium - B150)14:00 - 14:302 min Flash Poster Presentations from Invited Early Career Researchers (PE01-PE09)14:30 - 14:45O08: "Substituted Pyrrolidine Scaffolds for Library Production" by V. de Boer (Syncom)14:45 - 15:00O09: "Nature Inspired Small Molecules" by K. Kumar (MPI-Dortmund)15:00 - 15:15O10: "Powerful Strategies for the Synthesis of Spirocycles" by R. Megens (Mercachem)15:15 - 15:30Coffee Break (Auditorium - B150)15:30 - 16:002 min Flash Poster Presentations from Invited Early Career Researchers (PE10-PE19)16:00 - 16:15O11: "European Lead Factory: Scaffold Design and Synthesis" by D. Blanco (Radboud Univ.)16:15 - 16:30O12: "Natural Product Based Nortropane Analogues" by H. Adcock (Sygnature Discovery)16:30 - 16:45O13: "Synthesis of Dihydroisoquinolone Scaffolds and Fragments via Rh(III)-Catalysed C-H Activation" by T. Ackrill (Leeds Univ.)16:45 - 19:00Poster Session (ELF Partners and Invited Early Career Researcher; Atrium - B020)19:00 - 21:30Dinner (Janssen Cafe - B150; Bus transfer back to hotels at 21:45)

 

Agenda 7 November 2017
 

08:30Arrival at Janssen Campus (Bus transfer: 07:35 from Hotel Priorij Corsedonk, 07:55 from Corsedonk Viane)Oral Presentation Session III (Auditorium - B150)09:00 - 09:45 "PAINless Lead Generation:Validated Hit Series from the ELF" by P. Jones (Dundee Univ.)09:45 - 10:00O15: "Synthetic Challenges of Complex Library Scaffolds; How to handle Azides" by R. Dirks (Mercachem)10:00 - 10:15O16: "Novel Compact and Rigid Spiro-Libraries for Drug Discovery" by G. E. Akpinar (Taros Chemicals)10:15 - 11:00Coffee break (Atrium - B020) including conference photo (Auditorium - B150)11:00 - 11:30"New Leads for Pain-related Targets via ELF Collaboration" by A. McElroy (The Research Network)11:30 - 11:45O18: "Fused- and Spiro-bicyclic Systems containing a 1,4-diazepan-5-one core" by A. Cecchi (Syncom)12:00 - 13:00Lunch (Atrium - B020)Early Career Researcher Workshop on Hit-to-Lead (All Participants; Auditorium - B150)*13:00 - 13:45"HTS Case Study: Discovery of Potent Spiroazetidine-indolinones as M1 Positive Allosteric Modulators" by C. Martinez-Lamenca (Janssen)13:45 - 14:30"Fragment Based Screening Case Study: Fragment Based Drug Discovery of Selective Inhibitors of Fibroblast Growth Factor Receptor" by P. Angibaud (Janssen)14:30 - 15:15 "Phenotypic Screening Case Study: Activity in a Phenotypic Screening: What to Do Next? A NAMPT Story" by J. Linders (Janssen)15:15 - 16:00 Award ceremony, Photos and Wrap-up (Auditorium B150) **16:00End of Meeting

 


*Committee deliberation time during the workshop (13:00-14:30)
** As from previous L&A sessions, there will be two prize awards given to ELF Partners - best oral presentation (O02-O018) and best poster (P01-P13); 500 EUR each - and one prize for the best flash presentation (200 EUR) for an external participant (PE01-19). Prizes are sponsored by the ELF.