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16 June 2020

Cancer metabolism research bolstered by ELF collaboration

Metabomed, an Israeli biotech company that has been successful in progressing results through the European Lead Factory (ELF), has discovered a series of potent and selective inhibitors of ACSS2 (the AcetylCoA Short chain Synthase 2 enzyme) for the treatment of cancers dependent on acetate metabolism.

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10 June 2020

The power of innovative partnerships in driving drug discovery

Two scientists well-known within the European Lead Factory community, Peter Simpson and Graeme Wilkinson, recently published a paper discussing the features underpinning a successful drug discovery consortium.

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22 May 2020

In Memoriam: Professor dr. Huib Ovaa

Professor dr. Huib Ovaa, ELF Academic Chemistry Partner and Public Programme Owner passed away on the 19th of May 2020.

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15 May 2020

Study conducted in collaboration with ELF discovers brain compound can blur traumatic memories

An international team of researchers led by Leiden chemist Mario van der Stelt, have found that a naturally occurring compound in the brain, anandamide, contributes to the reduction of traumatic memories.

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12 May 2020

Project member spotlight: Patricia Kramer-Verhulst

In this, the first in a series of articles in which we introduce various members of the European Lead Factory (ELF) Consortium, we’re pleased to feature an interview with Patricia Kramer-Verhulst. Patricia is a member of the ELF Programme Office – a team of ELF project members at Lygature. We asked Patricia to explain her role and what it is that interests her most about the project.

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06 May 2020

ELF highlighted as part of IMI’s 12-year anniversary celebrations

In April, the Innovative Medicines Initiative (IMI) marked its 12th anniversary. To celebrate, it highlighted some of its early projects, one of which was the European Lead Factory (ELF). In several tweets and a special feature in the 100th edition of its newsletter, IMI reflected on the real-world impacts of the ELF project.

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23 April 2020

World Malaria Day: Raising awareness and celebrating progress

This Saturday is World Malaria Day. Marked each year on 25 April, the day is observed to raise awareness of the global burden of malaria and to celebrate the progress that has been made to combat it. This year, in the midst of the COVID-19 crisis, we are reminded of the importance of maintaining global prevention and control programmes to fight deadly infectious diseases like malaria.

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20 April 2020

The European Lead Factory and COVID-19

As the world grapples with the COVID-19 crisis, our European Lead Factory (ELF) Partners are working hard to contribute wherever they can to mitigate the impacts of the pandemic. At the same time, the ELF Consortium is looking for ways to contribute collective efforts and assets to help deal with the crisis.

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16 April 2020

ELF programmes available for partnering

Since its inception, the European Lead Factory (ELF) has been recruiting high quality drug discovery programmes from all over Europe. Over the past five years, the thorough recruitment and selection process has led to a balanced portfolio of innovative disease targets that have been screened against our unique compound library. We now have three successful ELF programmes in the field of CNS & Neurology available for partnering.

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16 March 2020

Phenotypic Screening now offered by the European Lead Factory

Phenotypic Screening is a powerful target-agnostic approach to identifying new chemical starting points for drug discovery. Furthermore, it offers the potential to uncover new targets and pathways underpinning disease-related biology.

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