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25 November 2020

Embracing the new normal: The European Lead Factory kicks off monthly webinar series

On Thursday 12 November, the European Lead Factory (ELF) hosted the first in a series of webinars. With these webinars, the ELF team aims to engage and maintain contact with the broader scientific community, now that live conferences and in-person meetings are not possible. The team also hopes to lower the barrier for researchers who may be interested in collaborating with ELF to further their drug discovery ambitions.

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04 November 2020

ELF project member spotlight: Jason Swedlow, University of Dundee

Phenotypic screening is a powerful approach to identifying novel chemical starting points for drug discovery, offering the potential to uncover new drug targets and pathways underpinning disease-related biology. High Content Screening (HCS) is one of the phenotypic screening approaches offered by the European Lead Factory (ELF). To find out more about HCS and all it entails, we spoke to Professor Jason Swedlow, head of the National Phenotypic Screening Centre (NPSC) at the University of Dundee – one of ELF’s academic partners.

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29 October 2020

Register now for the European Lead Factory webinar on 12 November

Registration is now open for the first in a series of webinars hosted by the European Lead Factory (ELF).

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26 October 2020

The European Lead Factory launches online seminar series

COVID-19 has led to in-person events being suspended or cancelled. In an effort to keep the European Lead Factory (ELF) community connected and informed of ongoing activities, we are pleased to announce that we will be organising a series of webinars on different programmes and topics within the ELF portfolio.

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09 October 2020

The European Lead Factory supports Mental Health Awareness Day

Saturday, 10 October is World Mental Health Awareness Day. As a project involved in advancing drug candidates to address mental health disorders and other diseases, the European Lead Factory (ELF) supports World Mental Health Awareness Day. At the ELF, there are several initiatives running that could ultimately contribute to better treatments of mental health conditions.

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24 August 2020

Hit discovery in the European Lead Factory: output and experiences of assay development and high throughput screening

In a paper recently published in the SLAS Discovery Journal of Biomolecular Screening, European Lead Factory (ELF) scientists from the Pivot Park Screening Centre (PPSC), shared their experiences working on the assay development and ultra-High Throughput Screening (u-HTS) of crowed-sourced drug targets during the first phase of ELF (2013-2018).

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20 August 2020

Weekly online Q&A hour

Do you want to know more about the European Lead Factory (ELF), or do you need some guidance on submitting your screening proposal to ELF? With the next proposal submission deadline fast approaching on 4 September, you don’t want to miss out on this opportunity to get some first-hand support.

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22 July 2020

The European Lead Factory selects first COVID-19 proposal

Over the last few months, as the world has grappled with the COVID-19 pandemic, the European Lead Factory has been looking for ways to contribute collective efforts and assets to help deal with the crisis. As part of this focus, we have decided to prioritise COVID-19 related proposals through a fast-track procedure. We're proud to announce that the first proposal to tackle the SARS-CoV-2 infection has now been selected. The screening program aims to identify small-molecule inhibitors of viral entry into host cells.

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22 July 2020

ELF project member spotlight: Sabine Mulders, PPSC

One of the objectives of the European Lead Factory (ELF) is to provide guidance to the drug discovery community on successful strategies in lead discovery techniques. Helping to achieve this objective is the Pivot Park Screening Centre (PPSC), the ELF partner responsible for assay development and high-throughput screening. To find out more about what’s involved in the assay development process and the interactions with researchers, we spoke to Sabine Mulders, Chief Project Officer at PPSC.

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16 June 2020

Cancer metabolism research bolstered by ELF collaboration

Metabomed, an Israeli biotech company that has been successful in progressing results through the European Lead Factory (ELF), has discovered a series of potent and selective inhibitors of ACSS2 (the AcetylCoA Short chain Synthase 2 enzyme) for the treatment of cancers dependent on acetate metabolism.

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