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20 February 2018

ELF use of the “hot” technique MST

The European Lead Factory (ELF) scientists are not shy of applying new techniques to deliver the best possible results. A recent perspective, published in SLAS Discovery, describes how getting hot (or not) can help in the triaging of primary HTS hits.

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06 February 2018

PhD thesis enhanced with ELF collaboration and compounds

On 30 January 2018, Stefan Baumeister defended his dissertation ‘Investigation of the properties of Acyl Protein Thioesterases and their role in Ras depalmitoylation’ at the Max Planck Institute of Molecular Physiology (MPI) in Dortmund. His thesis describes structural determinants for selectivity between two closely related enzymes. Specific inhibitors could be optimized thanks to compounds derived from Dr. Sonja Siever’s ELF programme. The new insights can prove important for understanding the role of these enzymes in the course of cancer. 

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31 January 2018

SciLifeLab signs Memorandum of Understanding

The SciLifeLab Director and the European Lead Factory executives of the European Screening Centre and the Public Chemistry Consortium have signed a Memorandum of Understanding for collaboration in future initiatives.

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10 January 2018

Oxford paper highlights JECL as good example of open science

The EU Lead Factory screening collection is assembled by and for both industry and public parties. This alternative innovation model is what the authors envision for the future.

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21 December 2017

European Lead Factory one of IMI’s most high-profile projects

Until now, the Innovative Medicines Initiative (IMI) has launched almost 100 projects to tackle the barriers that currently limit the efficiency, effectiveness and quality of medical research and drug development. 

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14 December 2017

The Research Network ELF experience

With six running target programmes, the virtual biotech The Research Network is unsurpassed in submitting interesting drug discovery programmes for screening by the European Lead Factory (ELF).

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12 December 2017

Joint European Compound Library >500 000 compounds

The European Lead Factory set out to assemble a screening collection of half a million compounds. Now, that ambitious goal has been reached. A truly pan-consortium achievement.

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11 December 2017

ELF sets screening record

During the lifetime of the European Lead Factory (ELF), both the number of screens performed per year and the size of the Joint European Compound Library have increased steadily. 

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28 November 2017

Spin-out Keapstone Therapeutics receives further funding

Based on the hits generated by the European Lead Factory, Dr Richard Mead, University of Sheffield, started the spin-out virtual biotech Keapstone Therapeutics, a world-first type of partnership between Parkinson's UK and the University of Sheffield. Keapstone Therapeutics aims to develop a new therapy for motor neurone disease (MND/ALS) and/or Parkinson’s disease.

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22 November 2017

ELF Chemistry event brings together scientists in Belgium

The European Lead Factory (ELF) acknowledges the need for open exchange between researchers with different professional backgrounds and puts a focus on the career development of young scientists. Therefore, the European Lead Factory annually invites young talented EU Lead Factory chemists from participating small and medium-sized enterprises (SMEs) and academic institutions to a so-called Learnings and Achievements meeting, where they can present their scientific work, interact with colleagues and liaise with representatives from participating established pharmaceutical companies and SME partners.

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