Since its launch in January 2013 and after having set up all necessary facilities, the European Lead Factory had rapidly delivered its first results. The first qualified hit list (QHL) was delivered in May 2014 and many more have followed since. The compounds in these lists have formed the basis of further programmes within the EU Lead Factory, which have resulted in highly active compounds validated with biochemical, biophysical and in some cases x-ray crystallographic data. For a more detailed overview of what programmes have delivered, go to the results page.
In addition, over 160,000 unprecedented compounds have already been synthesised and added to the Joint European Compound Library (JECL), which is on schedule for delivery of 200,000 novel compounds by end of 2017. Together with the more than 300,000 compounds of the EFPIA collection, over 500,000 compounds will then be available in the JECL for screening.
Become part of this success story! If you have a screening assay for a drug target or a novel library design idea, read more on the pages for drug target proposers or library design proposers on how you can benefit.
By 31 August 2017, 88 drug targets have been accepted by the Screening Selection Committee, for which 49 Qualified Hit Lists have been delivered so far by the European Screening Centre. Currently 35 programmes have progressed even further into the Improved Hit List phase, getting the opportunity to further develop these initial hits with additional studies funded by IMI (like resynthesis, hit expansion, DMPK and crystallography). So far, 20 Improved Hit Lists have been delivered and more than 30 crystal structures solved.
The Public Chemistry Consortium has now successfully validated >300 library proposals and has produced over 165,000 compounds (31 August 2017). Together with the compounds from EFPIA, more than 450,000 compounds are available in the Screening Set in 2017.
The goal is to have added 200,000 publicly-sourced compounds to the existing 300,000+ EFPIA compounds in the Joint European Compound Library by the end of 2017.