This is a non exhaustive list of publications related to ELF work published in scientific journals. Please contact the programme office if you miss a relevant publication.
Design and synthesis of 1,1-disubstituted-1-silacycloalkane-based compound libraries.
Synthesis of 1,4,5 trisubstituted γ-lactams via a 3-component cascade reaction
Cyclopentitol as a scaffold for a natural product-like compound library for drug discovery.
Synthesis of hexahydropyrrolo[2,1-a]isoquinoline compound libraries through a Pictet-Spengler cyclization/metal-catalyzed cross coupling/amidation sequence
Stereoselective synthesis of a natural product inspired tetrahydroindolo[2,3-a]-quinolizine compound library.
Branching cascades provide access to two amino-oxazoline compound libraries.
The European Lead Factory – An experiment in collaborative drug discovery
Laverty HG, Orrling KM, Giordanetto F, Poinot M, Ottow E, Rijnders TW, Tzalis D, Jaroch S
Journal of Medicines Development Sciences 1.1 (2015).
doi: 10.18063/JMDS.2015.01.009
Combining two-directional synthesis and tandem reactions. Part 21: Exploitation of a dimeric macrocycle for chain terminus differentiation and synthesis of an sp(3)-rich library.
Synthesis and functionalization of bicyclic N,O-acetal scaffolds from furfural.
Design, synthesis and decoration of molecular scaffolds for exploitation in the production of alkaloid-like libraries
Craven P, Aimon A, Dow M, Fleury-Bregeot N, Guilleux R, Morgentin R, Roche D, Kalliokoski T, Foster R, Marsden SP, Nelson A.
Bioorg Med Chem. 2015 Jun 1;23(11):2629-35.
doi: 10.1016/j.bmc.2014.12.048 . Epub 2014 Dec 29.
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