News
Recent publications based on screening of ELF assets
Two publications are out based on the exploitation of results coming out of the screening of the ELF Compound Library and the generation of the Public Compound Collection.
The first, a paper titled Synthesis of spirocyclic 1,2-diamines by dearomatising intramolecular diamination of phenols, was published in the Journal of Chemical Communications. The results of this study were based on the exploitation of scaffolds coming out of the ELF Public Compound Collection.
The second paper, published in the Journal of Medicinal Chemistry by authors from Merck Healthcare KGaA, looks at a KIT-selective inhibitor with best-in-class potential for the treatment of gastrointestinal stromal tumors (GISTs). The study saw the ELF Compound Library being named as the source of the original hit leading to one of the Drug Hunter Molecules of the Month in February.
View our publications page for a non-exhaustive list of publications related to the work of the European Lead Factory.