Publications

Publication
11.04.2018
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Realisation of small molecule libraries based on frameworks distantly related to natural products

Anthony Aimon, George Karageorgis, Jacob Masters, Mark Dow, Philip G. E. Craven, Martin Ohsten, Anthony Willaume, Rémy Morgentin, Nicolas Ruiz-Llamas, Hugues Lemoine, Tuomo Kalliokoski, Andrew J. Eatherton, Daniel J. Foley, Stephen P. Marsden, Adam Nelson
Organic & Biomolecular Chemistry 2018
doi: 10.1039/C8OB00688A 2018 April 11

Publication
20.02.2018
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Using Microscale Thermophoresis to Characterize Hits from High-Throughput Screening: A European Lead Factory Perspective

Julie M. Rainard, George C. Pandarakalam, Stuart P. McElroy 
SLAS Discovery 2018;23(3):225–241
doi: http://journals.sagepub.com/doi/10.1177/2472555217744728 2018 February 20, Open Access

Publication
15.02.2018
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Densely functionalised spirocyclic oxetane-piperidine scaffolds for drug discovery

Gemma C. Geary, Andrew Nortcliffe, Christopher A. Pearce, Daniel Hamza, Geraint Jones, Christopher J. Moody
Bioorganic & Medicinal Chemistry 2018;26(4):791-797
doi: https://doi.org/10.1016/j.bmc.2017.12.012 2018 February 15

Publication
16.11.2017
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Microwave-assisted Diastereoselective Two-step Three-component Synthesis for Rapid Access to Drug-like Libraries of Substituted 3-Amino-β-lactams

Guido V. Janssen, Joyce A.C. van den Heuvel, Rik P. Megens, Jorg C.J. Benningshof, Huib Ovaa
Bioorganic & Medicinal Chemistry (2017) 14066
doi: https://doi.org/10.1016/j.bmc.2017.11.014 Open Access

Publication
06.10.2017
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Synthesis and Demonstration of the Biological Relevance of sp3-rich Scaffolds Distantly Related to Natural Product Frameworks

Daniel J. Foley, Philip G. E. Craven, Patrick M. Collins, Richard G. Doveston, Anthony Aimon, Romain Talon, Ian Churcher, Frank von Delft, Stephen P. Marsden, Adam Nelson
Chem. Eur. J. 2017;23,15227
doi: https://doi.org/10.1002/chem.201704169 2017 October 10, Open Access

Publication
01.10.2017
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Piperidine and octahydropyrano[3,4-c]pyridine scaffolds for drug-like molecular libraries of the European Lead Factory

B.D. Narhe, A.C. Breman, J. Padwal, D.A.L. Vandenput, J.M. Scheidt, J.C.J. Benningshof, G.A. van der Marel, H.S. Overkleeft, M. van der Stelt, D.V. Filippov
Bioorganic & Medicinal Chemistry 2017; 25:5160–5170
doi: 10.1016/j.bmc.2017.07.016 2017 October 1

Publication
05.09.2017
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C−H Insertion as a Key Step to Spiro-Oxetanes, Scaffolds for Drug Discovery

Simon M. Nicolle, Andrew Nortcliffe, Hannah E. Bartrum, William Lewis, Christopher J. Hayes, Christopher J. Mood
Chem. Eur. J. 2017;23,13623
doi: https://doi.org/10.1002/chem.201703746 2017 September 5

Publication
29.06.2017
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Diastereoselective synthesis of novel heterocyclic scaffolds through tandem Petasis 3-component/intramolecular Diels–Alder and ROM–RCM reactions

Mette Ishoey, Rico G. Petersen,  Michael Å. Petersen, Peng Wu,  Mads H. Clausen, Thomas E. Nielsen
Chemical Communications 2017;53:9410-9413 
doi: 10.1039/C7CC02948A 2017 June 29  

Publication
13.06.2017
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Reference Module in Chemistry, Molecular Sciences and Chemical Engineering

F. Giordanetto, P. Jones, A. Nelson, J. Benningshof, G. Müller, A. Pannifer and D.Tzalis
Comprehensive Medicinal Chemistry III 2017, 505-519
doi:10.1016/B978-0-12-409547-2.12303-0 2017 June 13

Publication
05.06.2017
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Sulfur-Switch Ugi-Reaction For Macrocyclic Disulfide-Bridged Peptidomimetics

T. M. Vishwanatha, E. Bergamaschi and A. Dömling
Organic Letters Article ASAP 2017
doi: 10.1021/acs.orglett.7b01324 2017 June 5

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