News

The journal ‘Bioorganic & Medicinal Chemistry‘ has published a special issue on emerging approaches for the design and synthesis of small molecule libraries. Including 13 EU Lead Factory manuscripts, the European Lead Factory is strongly represented, demonstrating its high innovative character. All articles are available as open access publications.

Just a few months after its inclusion for drug target screening, one of the first compounds synthesised within the European Lead Factory was identified as a ‘drug-like’ hit.

The prestigious Bio-IT World Best Practices prize has been granted to the European Lead Factory (ELF) for its Honest Data Broker (HDB) implementation of the ScienceClo

Knowledge-sharing and education are key features of the European Lead Factory. Twice a year, chemistry PostDocs from within the consortium get the opportunity to present their research at the PostDoc Learnings and Achievements meeting.

During the European Lead Factory General Assembly meeting held on 26-27 March 2015 in Germany/Dortmund, Stefan Jaroch was introduced as the new project coordinator. 

CELLIPSE was awarded an exclusive High Throughput Screening research program to screen the EU Lead Factory’s (ELF) joint compound library on an undisclosed innovative therapeutic target, by the Selection Committee on January 19 2015.

NTRC, a biotech company based at Pivot Park in Oss, The Netherlands, is the first SME ever to receive a Qualified Hit List from the European Lead Factory that was generated using NTRC’s NFK GreenScreen™ assay technology. 

Topics in this issue: 1st publication on the character of the Joint European Compound Library - Crystal structures of QHL compounds with target -1stSME to receive a Qualified Hit List! -ELF Meeting: Chemistry Postdoc Learnings and Achievements -Meet the ELFs -Almost 40,000 JECL compounds synthesised - Status of JECL and Target Programmes

Our partner EDELRIS is celebrating 10 000 molecules prepared for the European Lead Factory project!

The European Screening Centre now also supports target assays with Ca2+ readout. Using an integrated FLIPR Tetra fully equipped with ICCD-camera, TetraCycler and heads ranging from 96 to 1536-well format, a wide range of real-time calcium kinetics and ion channel assays can be applied. 

Early confirmation of the drug-discovery potential of the European Lead Factory has emerged with delivery of the first two Qualified Hit Lists (QHLs).

Now open for online submissions:From today on, the ELF is happy to receive your novel scaffold ideas for evaluation. 

The European Lead Factory project is now accepting proposals for target programmes from project partners as well as external academics and small and medium-sized enterprises (SMEs).

Nature magazine ranked the European Lead Factory among the bright spots in science around the globe in its review of 2013's most important developments in biomedical research.